Chemistry

Catherine D. Clark
- Chemistry - Professor
Person: Faculty
Tim Kowalczyk
- Chemistry - Assistant Professor
- Advanced Materials Science & Engineering Center (AMSEC) - Assistant Professor of Physical & Computational Chemistry
- Institute for Energy Studies - Assistant Professor
Person: Faculty
Gregory W. O'Neil
- Institute for Energy Studies - Affiliated Faculty
- Chemistry - Professor, Department of Chemistry
Person: Faculty
David L. Patrick
- Institute for Energy Studies - Affiliated Faculty
- Chemistry - Professor, Department of Chemistry
Person: Faculty
P. Clint Spiegel
- Chemistry - Professor, Biochemistry
Person: Faculty

170 Article
10 Presentation
4 Chapter
3 Comment/debate
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Atomistic Mechanism of Lipid Membrane Binding for Blood Coagulation Factor VIII with Molecular Dynamics Simulations on a Microsecond Time Scale
Avery, N. G., Childers, K. C., McCarty, J. & Spiegel, P. C., Feb 6 2025, In: Journal of Physical Chemistry B. 129, 5, p. 1486-1498 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Biophysical characterization of blood coagulation factor VIII binding to lipid nanodiscs that mimic activated platelet surfaces
Avery, N. G., Young, I. R., Lu, S., Vaughan, J. D., Korus, P. S., Richardson, T. N., Childers, K. C., Smirnov, S. L. & Spiegel, P. C., Feb 2025, In: Journal of Thrombosis and Haemostasis. 23, 2, p. 513-524 12 p.
Research output: Contribution to journal › Article › peer-review
Diastereoselective β-hydroxy vinylsulfone isomerizations
O'Neil, G. W., Clark, T. D., Jones, A. P., Wallace, C., Carnahan, D. M. & Crockett, H., Jan 10 2025, In: Organic and Biomolecular Chemistry. 23, 8, p. 1883-1893 11 p.
Research output: Contribution to journal › Article › peer-review
Intermolecular N-N Coupling of a Dinitrosyl Iron Complex Induced by Hydrogen Bond Donors in the Secondary Coordination Sphere
Fugami, K. M., Black, G. S., Kowalczyk, T., Seda, T. & Gilbertson, J. D., Mar 5 2025, In: Journal of the American Chemical Society. 147, 9, p. 7274-7281 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Production of dissolved organic matter from lily pads (Nymphaea odorata) in a mesotrophic freshwater lake
Juetten, K., De Bruyn, W. J., Landram, Z., Jansen, C. D. R., Harrison, A. W., Strecker, A. & Clark, C. D., Apr 2025, In: Aquatic Sciences. 87, 2, 55.
Research output: Contribution to journal › Article › peer-review
Recent Developments in DFTB+, a Software Package for Efficient Atomistic Quantum Mechanical Simulations
Hourahine, B., Berdakin, M., Bich, J. A., Bonafé, F. P., Camacho, C., Cui, Q., Deshaye, M. Y., Díaz Mirón, G., Ehlert, S., Elstner, M., Frauenheim, T., Goldman, N., González León, R. A., van der Heide, T., Irle, S., Kowalczyk, T., Kubař, T., Lee, I. S., Lien-Medrano, C. R. & Maryewski, A. & 12 others, Melson, T., Min, S. K., Niehaus, T., Niklasson, A. M. N., Pecchia, A., Reuter, K., Sánchez, C. G., Scheurer, C., Sentef, M. A., Stishenko, P. V., Vuong, V. Q. & Aradi, B., Jun 19 2025, In: Journal of Physical Chemistry A. 129, 24, p. 5373-5390 18 p.
Research output: Contribution to journal › Article › peer-review
TBAT-catalyzed dioxasilinane formation from beta-hydroxy ketones
Peterson, H. J. & O'Neil, G. W., Feb 1 2025, In: Tetrahedron. 171, 134418.
Research output: Contribution to journal › Article › peer-review
Time-resolved fluorescence measurements of dissolved organic matter (DOM) as a function of environmental parameters in estuarine waters
de Bruyn, W. J., Manickam, D., Harrison, A. W. & Clark, C. D., Jan 2025, In: Environmental Science and Pollution Research. 32, 4, p. 1952-1970 19 p.
Research output: Contribution to journal › Article › peer-review
Antimicrobial isoflavans and other metabolites of Dalea nana
Belofsky, G., Cruz, C., Schultz, T., Zapata, M., Wilcox, D., Wasmund, B., Salomon, C. E. & Spiegel, P. C., Oct 2024, In: Phytochemistry. 226, 114224.
Research output: Contribution to journal › Article › peer-review
Blunting specific T-dependent antibody responses with engineered “decoy” B cells
Pitner, R. A., Chao, J. L., Dahl, N. P., Fan, M. N., Cai, X., Avery, N. G., Roe, K., Spiegel, P. C., Miao, C. H., Gerner, M. Y., James, R. G. & Rawlings, D. J., Oct 2 2024, In: Molecular Therapy. 32, 10, p. 3453-3469 17 p.
Research output: Contribution to journal › Article › peer-review
Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction
Coyle, C. W., Knight, K. A., Brown, H. C., George, S. N., Denning, G., Branella, G. M., Childers, K. C., Spiegel, P. C., Spencer, H. T. & Doering, C. B., Mar 2024, In: Journal of Thrombosis and Haemostasis. 22, 3, p. 633-644 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Hydroxyl-Directed Regio- and Diastereoselective Allylic Sulfone Reductions with [Sm(H₂O)_n]I₂
Schwans, C. L., Clark, T. D. & O’Neil, G. W., Jan 5 2024, In: Journal of Organic Chemistry. 89, 1, p. 692-700 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Iodine Rearrangements of Tetraallylsilane and Synthesis of Silicon-Stereogenic Organosilanes
Tan, E. D., Wier, K. E. & O’Neil, G. W., Sep 2024, In: International Journal of Molecular Sciences. 25, 18, 9996.
Research output: Contribution to journal › Article › peer-review

Open Access
Monitoring Changes to Alkenone Biosynthesis in Commercial Tisochrysis lutea Microalgae
O’Neil, G. W., Keller, A., Balila, J., Golden, S., Sipila, N., Stone, B., Nelson, R. K. & Reddy, C. M., Apr 9 2024, In: ACS Omega. 9, 14, p. 16374-16383 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Regioselective Fluorohydrin Synthesis from Allylsilanes and Evidence for a Silicon-Fluorine Gauche Effect
Clover, A. W., Jones, A. P., Berger, R. F., Kaminsky, W. & O’Neil, G. W., Apr 5 2024, In: Journal of Organic Chemistry. 89, 7, p. 4309-4318 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Simulation of interlayer coupling for electroactive covalent organic framework design
Leo, T. M., Robbins, M., Sullivan, A., Thornes, H., Fitzsimmons, G., Goodey, A. & Kowalczyk, T., May 14 2024, In: Journal of Chemical Physics. 160, 18, 184704.
Research output: Contribution to journal › Article › peer-review
Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain
Childers, K. C., Cowper, B., Vaughan, J. D., McGill, J. R., Davulcu, O., Lollar, P., Doering, C. B., Coxon, C. H. & Spiegel, P. C., Sep 2024, In: Journal of Thrombosis and Haemostasis. 22, 9, p. 2449-2459 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Time-resolved fluorescence of oils and oil distillates in artificial seawater at low excitation wavelengths: Assessing the use of lifetimes to decouple oil and dissolved organic matter (DOM) fluorophores in natural waters
de Bruyn, W. J., Harrison, A. W., Kocik, E., Manickam, D., Truong, E. & Clark, C. D., Dec 2024, In: Marine Pollution Bulletin. 209, 117073.
Research output: Contribution to journal › Article › peer-review
Building Blocks and COFs Formed in Concert—Three-Component Synthesis of Pyrene-Fused Azaacene Covalent Organic Framework in the Bulk and as Films
Frey, L., Oliveira, O., Sharma, A., Guntermann, R., Fernandes, S. P. S., Cid-Seara, K. M., Abbay, H., Thornes, H., Rocha, J., Döblinger, M., Kowalczyk, T., Rao, A., Salonen, L. M. & Medina, D. D., Jul 24 2023, In: Angewandte Chemie - International Edition. 62, 30, e202302872.
Research output: Contribution to journal › Article › peer-review

Open Access
Electronic transition dipole moments from time-independent excited-state density-functional tight-binding
Deshaye, M. Y., Wrede, A. T. & Kowalczyk, T., Apr 7 2023, In: Journal of Chemical Physics. 158, 13, 134104.
Research output: Contribution to journal › Article › peer-review
Sequential Deoxygenation of CO₂ and NO₂^- via Redox-Control of a Pyridinediimine Ligand with a Hemilabile Phosphine
Lewine, H. R., Teigen, A. G., Trausch, A. M., Lindblom, K. M., Seda, T., Reinheimer, E. W., Kowalczyk, T. & Gilbertson, J. D., Sep 18 2023, In: Inorganic Chemistry. 62, 37, p. 15173-15179 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Structure of coagulation factor VIII bound to a patient-derived anti–C1 domain antibody inhibitor
Childers, K. C., Avery, N. G., Estrada Alamo, K. A., Davulcu, O., Haynes, R. M., Lollar, P., Doering, C. B., Coxon, C. H. & Spiegel, P. C., Jul 13 2023, In: Blood. 142, 2, p. 197-201 5 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Accessible and Efficient Modeling of Chromophores with Time-Independent Excited-State Density Functional Tight-Binding: Concepts and Applications
Deshaye, M. Y., Pollard, Z. A., Banducci, A., Goodey, A., Prommin, C., Kanlayakan, N., Kungwan, N. & Kowalczyk, T., Nov 21 2022, ACS Symposium Series. Hopkins, T. A. & Parish, C. A. (eds.). American Chemical Society, p. 125-144 20 p. (ACS Symposium Series; vol. 1429).
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Antimicrobial Isoflavans and Other Metabolites of Dalea jamesii
Belofsky, G., Ahn, H., Zapata, M., Wilcox, D., Salomon, C. E. & Spiegel, P. C., Oct 5 2022, In: Planta Medica. 89, 7, p. 754-763 10 p.
Research output: Contribution to journal › Article › peer-review
Assessment of the anthelmintic activity and toxicity of metabolites of Dalea pogonathera (Fabaceae)
McPherson, V., Wolhart, H., Engels, L., Sullivan, K., Coria, A., Bicchieri, T., Torrey, B., Spiegel, P. C., Danforth, S., Belofsky, G. & Dondji, B., Oct 2022, In: Phytochemistry Letters. 51, p. 75-81 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Chromophoric Dissolved Organic Matter and Dissolved Organic Carbon in Lakes Across an Elevational Gradient From the Mountains to the Sea
Juetten, K., Strecker, A. L., Harrison, A., Landram, Z., De Bruyn, W. J. & Clark, C. D., Dec 1 2022, In: Biology, Chemistry, and Environmental Sciences Faculty Articles and Research.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Erratum: DFTB+, a software package for efficient approximate density functional theory based atomistic simulations (Journal of Chemical Physics (2020) 152 (124101) DOI: 10.1063/1.5143190)
Hourahine, B., Aradi, B., Blum, V., Bonafé, F., Buccheri, A., Camacho, C., Cevallos, C., Deshaye, M. Y., Dumitrica, T., Dominguez, A., Ehlert, S., Elstner, M., Van Der Heide, T., Hermann, J., Irle, S., Jakowski, J., Kranz, J. J., Köhler, C., Kowalczyk, T. & Kubař, T. & 20 others, Lee, I. S., Lutsker, V., Maurer, R. J., Min, S. K., Mitchell, I., Negre, C., Niehaus, T. A., Niklasson, A. M. N., Page, A. J., Pecchia, A., Penazzi, G., Persson, M. P., Rezáč, J., Sánchez, C. G., Sternberg, M., Stöhr, M., Stuckenberg, F., Tkatchenko, A., Yu, V. W. Z. & Frauenheim, T., Jul 21 2022, In: Journal of Chemical Physics. 157, 3, 039901.
Research output: Contribution to journal › Comment/debate › peer-review

Open Access
Quantum Dot-Block Copolymer Hybrids for Low Scattering Luminescent Solar Concentrators
Koch, K. C., Korus, D., Doyle, J., Plummer, M., Boxx, M., Win-Piazza, H., McDowall, S., Patrick, D. L. & Rider, D. A., May 13 2022, In: ACS Applied Polymer Materials. 4, 5, p. 3283-3293 11 p.
Research output: Contribution to journal › Article › peer-review
SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa
Childers, K. C., Peters, S. C., Lollar, P., Spencer, H. T., Doering, C. B. & Spiegel, P. C., Jun 14 2022, In: Blood Advances. 6, 11, p. 3240-3254 15 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Shining a light on thrombin activation
Spiegel, P. C., Jun 16 2022, In: Blood. 139, 24, p. 3451-3453 3 p.
Research output: Contribution to journal › Editorial › peer-review

Open Access

Western Washington University Reports Findings in Science (Intermolecular N-N Coupling of a Dinitrosyl Iron Complex Induced by Hydrogen Bond Donors in the Secondary Coordination Sphere)
Seda, T. & Kowalczyk, T.
3/3/25
1 item of Media coverage
Press/Media: Research
Peptide discovery could advance treatment of high blood pressure
Patrick, D. L.
9/9/24
1 item of Media coverage
Press/Media: Research
Reports from Western Washington University Describe Recent Advances in Chemical Physics (Simulation of interlayer coupling for electroactive covalent organic framework design)
Kowalczyk, T.
5/23/24
1 item of Media coverage
Press/Media: Research
Utah officially adds a new face to the Runnin' Utes coaching staff
Patrick, D. L.
5/17/24
1 item of Media coverage
Press/Media: Research
What new assistant coach Loren Leath brings to Runnin’ Utes coaching staff
Patrick, D. L.
5/17/24
1 item of Media coverage
Press/Media: Research
Western Washington University and Washington Research Foundation Partner on New Western Innovation Training Fellowship
O'Neil, G. W. & Wallin, D. O.
4/25/24
1 item of Media coverage
Press/Media: Research
Findings from Western Washington University Update Knowledge of Chemicals and Chemistry (Monitoring Changes To Alkenone Biosynthesis In Commercial Tisochrysis Lutea Microalgae)
O'Neil, G. W.
4/24/24
1 item of Media coverage
Press/Media: Research
Western Washington University and Washington Research Foundation partner on new Western Innovation Training Fellowship
O'Neil, G. W. & Wallin, D. O.
4/24/24
1 item of Media coverage
Press/Media: Research
Western Washington University Reports Findings in Science (Regioselective Fluorohydrin Synthesis from Allylsilanes and Evidence for a Silicon-Fluorine Gauche Effect)
O'Neil, G. W.
3/21/24
1 item of Media coverage
Press/Media: Research
U.S. Patents Awarded to Inventors in Massachusetts (Dec. 13)
O'Neil, G. W.
12/13/23
1 item of Media coverage
Press/Media: Research
Alkenone-Based Formulations for Topical Applications
O'Neil, G. W.
12/12/23 → 12/13/23
2 items of Media coverage
Press/Media: Research
U.S. Patents Awarded to Inventors in Washington (Dec. 13)
O'Neil, G. W.
12/13/23
1 item of Media coverage
Press/Media: Research
Western Washington University Reports Findings in Science (Sequential Deoxygenation of CO2 and NO2- via Redox-Control of a Pyridinediimine Ligand with a Hemilabile Phosphine)
Seda, T. & Kowalczyk, T.
9/14/23
1 item of Media coverage
Press/Media: Research
Upwell Cosmetics in Woods Hole gets patents for algae-based cosmetics
O'Neil, G. W.
7/20/23
1 item of Media coverage
Press/Media: Research
Going all natural; Upwell Cosmetics in Woods Hole gets patents for algae-based cosmetics
O'Neil, G. W.
7/16/23
1 item of Media coverage
Press/Media: Research
Lipsticks, shampoo from algae: Woods Hole company intends to disrupt personal care market
O'Neil, G. W.
7/13/23
1 item of Media coverage
Press/Media: Research
Upwell Cosmetics in Woods Hole gets patents for algae-based cosmetics
O'Neil, G. W.
7/13/23
1 item of Media coverage
Press/Media: Research
Making Petroleum-Based Wax a Thing of the Past with Ocean-Friendly Alternatives
O'Neil, G. W.
5/8/23
1 item of Media coverage
Press/Media: Research
US Patent Issued to Woods Hole Oceanographic Institution, Western Washington University, Marine Biological Laboratory on April 25 for "Use of marine algae for co-producing alkenones, alkenone derivatives, and co-products" (Massachusetts, Wisconsin Invento
O'Neil, G. W.
4/26/23
1 item of Media coverage
Press/Media: Research
Upwell Cosmetics Brings Revolutionary New Algae-Derived Wax That Can Replace Harmful Petroleum In Cosmetics And Personal Care Products
O'Neil, G. W.
4/6/23
1 item of Media coverage
Press/Media: Research
Air Force to install New Mexico-made solar windows
Patrick, D. L.
8/24/22
2 items of Media coverage
Press/Media: Research
Air Force to install New Mexico-made solar windows
Patrick, D. L.
8/24/22
2 items of Media coverage
Press/Media: Research
US Air Force funds “quantum dot” photovoltaic window project
Patrick, D. L.
8/18/22
1 item of Media coverage
Press/Media: Research
U.S. Air Force Awards UbiQD Contracts for Photovoltaic Window Technology
Patrick, D. L.
8/18/22
1 item of Media coverage
Press/Media: Research
US Nanotech Developer UbiQD Awarded SBIR Contracts By US Air Force
Patrick, D. L.
8/18/22
1 item of Media coverage
Press/Media: Research
US Nanotech Developer UbiQD Awarded SBIR Contracts By US Air Force
Patrick, D. L.
8/18/22
1 item of Media coverage
Press/Media: Research
US Air Force funds ‘quantum dot’ photovoltaic window project
Patrick, D. L.
8/18/22
1 item of Media coverage
Press/Media: Research
U.S. Air Force Funds Photovoltaic Window Technology on Military Bases
Patrick, D. L.
8/17/22
54 items of Media coverage
Press/Media: Research
If Kasari Govender won't order a public inquiry into the government's response to COVID-19, then who will?
Patrick, D. L.
7/3/22
1 item of Media coverage
Press/Media: Research
UPDATE ON SEARCH FOR NEW HUXLEY COLLEGE DEAN
Bauman, J. M., Strecker, A., Paci-Green, R., Patrick, D. L. & Sofield, R.
11/23/21
1 item of Media coverage
Press/Media: Research

Chemistry

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